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刘喜红

职　　务：

职　　称：青年研究员、硕士生导师

电子邮箱：liuxihong@lzu.edu.cn

科研方向：多肽修饰、不对称合成、小分子及多肽药物

个人简介：

刘喜红，男，理学博士，新利官网手机网页版/甘肃省新药临床前研究重点实验室青年研究员，硕士生导师。2013年于新利官网手机网页版生命科学学院生物科学专业（基地班）获理学学士学位；2019年于新利官网手机网页版生命科学学院生物化学与分子生物学专业获理学博士学位，师从王锐院士。目前主要研究方向为非天然氨基酸和螺旋手性分子的对映选择性合成及基于修饰新策略的多肽构效关系研究，在国际著名期刊Nat. Commun.、Angew. Chem. Int. Ed.、Chem. Sci.、ACS Catal.、Green Chem.、Org. Chem. Front.等杂志发表SCI论文19篇，其中以第一作者和通讯作者发表论文8篇。近五年主持国家自然科学基金项目2项，甘肃省自然科学基金项目1项。

受教育经历：

2013.09-2019.06  新利官网手机网页版生命科学学院，生物化学与分子生物学，博士

2009.09-2013.06  新利官网手机网页版生命科学学院，生物科学基地班，学士

工作经历：

2020.03-至今  新利官网手机网页版、甘肃省新药临床前研究重点实验室，青年研究员

 

多肽修饰、不对称合成、小分子及多肽药物

主持科研项目：

  1. “双一流”引导专项-队伍建设经费-科研启动费，2020.03-2025.03（在研）；
  2. 国家自然科学基金青年基金项目，批准号：22001103，2021.01-2023.12（已结题）；
  3. 国家自然科学基金面上项目，批准号：22371099，2024.01-2027.12（在研）；
  4. 甘肃省自然科学基金青年科技基金，批准号：23JRRA1115，2023.07-2025.06（在研）。

发表论文

  1. Xihong Liu*, Boyan Zhu, Xiaoyong Zhang, Hanwen Zhu, Jingying Zhang, Aiqi Chu, Fujun Wang and Rui Wang*, Nat. Commun., 2024, 15, 732-743. (SCI一区, IF2023 = 16.6)
  2. Xihong Liu*, Boyan Zhu, Panpan Zhou, Jingying Zhang, Anqi Chu and Rui Wang*, Org. Chem. Front., 2024, DOI: 10.1039/D4QO00103F. (SCI一区, IF2023 = 5.4)
  3. Xihong Liu, Jingying Zhang, Lutao Bai, Linqing Wang, Dongxu Yang* and Rui Wang*, Catalytic asymmetric multiple dearomatizations of phenols enabled by a cascade 1,8-addition and Diels–Alder reaction. Chem. Sci., 2020, 11, 671-676. (SCI一区, IF2023 = 8.4; Inside back cover)
  4. Xihong Liu, Pengxin Wang, Lutao Bai, Dan Li, Linqing Wang*, Dongxu Yang and Rui Wang*, Construction of Vicinal All-Carbon Quaternary Stereocenters Enabled by a Catalytic Asymmetric Dearomatization Reaction of β‑Naphthols with 3‑Bromooxindoles. ACS Catal., 2018, 8, 10888-10894. (SCI一区, IF2023 = 12.9)
  5. Xihong Liu, Dongxu Yang, Kezhou Wang, Jinlong Zhang and Rui Wang*, A catalyst-free 1,3-dipolar cycloaddition of C,N-cyclic azomethine imines and 3-nitroindoles: an easy access to five-ring-fused tetrahydroisoquinolines. Green Chem., 2017, 19, 82-87. (SCI一区, IF2023 = 9.8)
  6. Xihong Liu#, Yijie Wang#, Dongxu Yang, Jinlong Zhang, Dongsheng Liu* and Wu Su*, Catalytic Asymmetric Inverse-Electron-Demand 1,3-Dipolar Cycloaddition of C,N-Cyclic Azomethine Imines with Azlactones: Access to Chiral Tricyclic Tetrahydroisoquinolines. Angew. Chem. Int. Ed., 2016, 55, 8100-8103. (SCI一区, IF2023 = 16.6)
  7. Xihong Liu#, Jinlong Zhang#, Long Zhao, Shixiong Ma, Dongxu Yang, Wenjin Yan and Rui Wang*, Construction of Vicinal Tetrasubstituted Stereocenters with a C−F Bond through a Catalytic Enantioselective Detrifluoroacetylative Mannich Reaction. J. Org. Chem., 2015, 80, 12651-12658. (SCI二区, IF2023 = 3.6)
  8. Xihong Liu, Jinlong Zhang, Shixiong Ma, Yunxia Ma and Rui Wang*, Oxidative cross-dehydrogenative coupling between N-aryl tetrahydroisoquinolins and 5H-oxazol-4-ones through two methodologies: copper catalysis or a metal-free strategy. Chem. Commun., 2014, 50, 15714-15717. (SCI二区, IF2023 = 4.9)
  9. Jinlong Zhang#, Xihong Liu# and Rui Wang*, Magnesium Complexes as Highly Effective Catalysts for Conjugate Cyanation of α,β-Unsaturated Amides and Ketones. Chem. Eur. J., 2014, 20, 4911-4915. (SCI二区, IF2023 = 4.3)
  10. Jinlong Zhang, Xihong Liu, Chongyang Wu, Panpan Zhang, Jianbo Chen and Rui Wang*, Organocatalyzed Asymmetric 1,4-Addition of Azlactones to α,β-Unsaturated Trichloromethyl Ketones: Synthesis of α,α-Disubstituted α-Amino Acid Derivatives. Eur. J. Org. Chem., 2014, 7104–7108. (SCI三区, IF2023 = 2.8)
  11. Jinlong Zhang, Xihong Liu, Xiaojuan Ma and Rui Wang*, Organocatalyzed asymmetric vinylogous Michael addition of α,β-unsaturated γ-butyrolactam. Chem. Commun., 2013, 49, 9329-9331. (SCI二区, IF2023 = 4.9)
  12. Jinlong Zhang, Xihong Liu, Xiaojuan Ma and Rui Wang*, Direct asymmetric aldol addition-isomerization of α,β-unsaturated γ-butyrolactam with aryl γ-ketoesters: synthesis of MBH-type products. Chem. Commun., 2013, 49, 3300-3302. (SCI二区, IF2023 = 4.9)
  13. Kezhou Wang#, Chao Chen#*, Xihong Liu, Dan Li, Tianyu Peng, Xin Liu, Dongxu Yang and Linqing Wang*, Enantioselective Reaction between 2‑(Cyanomethyl)azaarenes and N‑Boc-amino Sulfones. Org. Lett., 2018, 20, 5260-5263. (SCI一区, IF2023 = 5.2)
  14. Kezhou Wang, Linqing Wang, Xihong Liu, Dan Li, Haiyong Zhu, Pengxin Wang, Yuyang Liu, Dongxu Yang* and Rui Wang*, Development of Biligands Magnesium Catalysis in Asymmetric Conjugate Reactions of C3-Pyrrolyl-Oxindoles. Org. Lett., 2017, 19, 4351-4354. (SCI一区, IF2023 = 5.2)
  15. Linqing Wang#, Dongxu Yang#, Dan Li, Xihong Liu, Qian Zhao, Ranran Zhu, Bangzhi Zhang and Rui Wang*, Catalytic Asymmetric [3+2] Cyclization Reactions of 3‑Isothiocyanato Oxindoles and Alkynyl Ketones Via an in Situ Generated Magnesium Catalyst. Org. Lett., 2015, 17, 4260-4263. (SCI一区, IF2023 = 5.2)
  16. Dan Li, Dongxu Yang*, Linqing Wang, Xihong Liu, Kezhou Wang, Jie Wang, Pengxin Wang, Yuyang Liu, Haiyong Zhu and Rui Wang*, An Efficient Nickel-Catalyzed Asymmetric Oxazole-Forming Ugi-Type Reaction for the Synthesis of Chiral Aryl-Substituted THIQ Rings. Chem. Eur. J., 2017, 23, 6974-6978. (SCI二区, IF2023 = 4.3)
  17. Dan Li, Dongxu Yang*, Linqing Wang, Xihong Liu, Xianxing Jiang* and Rui Wang*, MgII-Catalyzed Desymmetrization Reaction of meso-Aziridines with Hydroxylamines: Synthesis of Novel Chiral 1,2-Diamine Skeletons. Chem. Eur. J., 2016, 22, 17141-17144. (SCI二区, IF2023 = 4.3)
  18. Linqing Wang, Dongxu Yang*, Dan Li, Xihong Liu, Pengxin Wang, Kezhou Wang, Haiyong Zhu, Lutao Bai and Rui Wang*, The Important Role of the Byproduct Triphenylphosphine Oxide in the Magnesium(II)-Catalyzed Enantioselective Reaction of Hemiacetals and Phosphorus Ylides. Angew. Chem. Int. Ed., 2018, 57, 9088-9092. (SCI一区, IF2023 = 16.6)
  19. Qiao Chen, Jiawei Zhou, Yanan Wang, Chao Wang, Xihong Liu, Zhaoqing Xu*, Li Lin and Rui Wang*, Transition-Metal-Free Dehydrosilylative Difluoroamidation of Tetrahydroisoquinolines under Mild Conditions. Org. Lett., 2015, 17, 4212-4215. (SCI一区, IF2023 = 5.2)

学院地址: 甘肃省兰州市东岗西路199号 新利官网手机网页版 邮编: 730000

电 话: 0931-8915023 8915092

传真: 0931-8915023

电子邮箱: jcyxy@lzu.edu.cn